VACCINES

Quillaja saponins are excellent adjuvants for the production of animal vaccines. To avoid reactions at the injection site, purified fractions have to be used. Natural Response offers three products: QP UF 300, QP UF 1000 and Vax-Sap.
Some commercial vaccines prepared with quillaja saponins are rabies, foot-and-mouth disease, bovine mastitis and feline leukemia.

LITERATURE
1. Cainelli Gebara, V.; Petricevich, V.; Rau, I.; da Silva, W. (1995) Effect of saponin Quillaja saponaria Molina on antibody, tumor necrosis factor and interferon-gamma production. Biotecnol. Appl. Biochem. 22: 31-7.
2. Kamstrup, S., San Martín, R., Doberti, A., Grande, H., Dalsgaard, K. (2000) Preparation and characterization of quillaja saponin with less heterogeneity than Quil-A. Vaccine, 18: 2244 -2249.
3. Kensil, Ch.; Patel, U.; Alnico, M.; Macron, D. (1991) Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J. Immunol.. 146: 431-7
4. Kensil, C. R. (1996). Saponins as Vaccine Adjuvants. Critical reviews in Therapeutic Drug Carrier Systems, 13: 1 - 55.
5. San Martín, R. and Briones, R. 1999. Industrial uses and sustainable supply of Quillaja saponaria saponins. Economic Botany, 53, 302-311